Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | ESR1 | P03372 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619920 | 0.95 | MAPT (0.39) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL8621923 | 0.91 | MAPT (0.38) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL8615788 | 0.91 | KMT2A (0.44) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL8621073 | 0.89 | MAPT (0.46) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL8617441 | 0.88 | MAPT (0.41) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL8619814 | 0.87 | LMNA (0.44) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| Atrimustine SCHEMBL10580413 | 0.87 | LMNA (0.56) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| Atrimustine SCHEMBL8659 | 0.87 | LMNA (0.56) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| Atrimustine SCHEMBL29359877 | 0.87 | LMNA (0.56) | MAPTLMNAKMT2ACYP3A4MEN1 | |
| SCHEMBL8622449 | 0.85 | LMNA (0.43) | MAPTLMNAKMT2ACYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573977-B1 | Novel estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 1998-05-13 | — | — | EP | disclosed |