Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 16/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 14/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 13/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 10/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.43 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.40 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619749 | 1.00 | ENPP2 (0.50) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL27416857 | 0.99 | ENPP2 (0.49) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL8618052 | 0.95 | ENPP2 (0.45) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL8618048 | 0.95 | ENPP2 (0.45) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| Potassium SCHEMBL9161975 | 0.94 | ENPP2 (0.44) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL9161959 | 0.94 | ENPP2 (0.44) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL8623068 | 0.87 | FDFT1 (0.38) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8623064 | 0.87 | FDFT1 (0.38) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8625391 | 0.86 | S1PR1 (0.41) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL8625397 | 0.86 | S1PR1 (0.41) | ENPP2S1PR1S1PR3S1PR2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | claimed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | claimed |
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |