Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 7/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.43 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 5/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618052 | 0.99 | ENPP2 (0.45) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8618048 | 0.99 | ENPP2 (0.45) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL9161959 | 0.98 | ENPP2 (0.44) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8619749 | 0.94 | ENPP2 (0.50) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8619747 | 0.94 | ENPP2 (0.50) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL27416857 | 0.93 | ENPP2 (0.49) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8623064 | 0.91 | FDFT1 (0.38) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8623068 | 0.91 | FDFT1 (0.38) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8625440 | 0.86 | FDFT1 (0.40) | ENPP2S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8625446 | 0.86 | FDFT1 (0.40) | ENPP2S1PR1S1PR3S1PR2LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |