Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 14/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617949 | 0.89 | SMO (0.46) | SMOSCN5ASCN2ARAB9ALMNA | |
| SCHEMBL8614046 | 0.86 | SMO (0.49) | SMOSCN5ASCN2ARAB9ALMNA | |
| SCHEMBL8616484 | 0.86 | SMO (0.49) | SMOSCN5ASCN2ARAB9ALMNA | |
| SCHEMBL8618668 | 0.86 | SMO (0.43) | SMOSCN5ASCN2ARAB9ALMNA | |
| Hydrochloric Acid SCHEMBL8615174 | 0.85 | SMO (0.42) | SMOSCN5ASCN2ARAB9ALMNA | |
| SCHEMBL8620636 | 0.84 | NPC1 (0.49) | SMOSCN5ASCN2ARAB9ALMNA | |
| SCHEMBL8620870 | 0.84 | SRC (0.47) | SMORAB9ALMNANPC1PSMD14 | |
| SCHEMBL8613207 | 0.84 | SMO (0.49) | SMOSCN5ASCN2ARAB9ALMNA | |
| SCHEMBL8614772 | 0.83 | SMO (0.43) | SMOSCN5ASCN2ARAB9ALMNA | |
| SCHEMBL8614354 | 0.81 | SMO (0.43) | SMOSCN5ASCN2ARAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |