Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 18/20 | 0.49 |
| ▸ | PPARG | P37231 | 17/20 | 0.49 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619819 | 0.91 | LAP3 (0.43) | PPARAPPARGACP3ANPEPLAP3 | |
| SCHEMBL8618892 | 0.91 | LAP3 (0.43) | PPARAPPARGACP3ANPEPLAP3 | |
| SCHEMBL8621232 | 0.91 | LAP3 (0.43) | PPARAPPARGACP3ANPEPLAP3 | |
| SCHEMBL8624054 | 0.88 | ALDH1A1 (0.41) | PPARAPPARGACP3 | |
| SCHEMBL8626353 | 0.88 | PPARG (0.49) | PPARAPPARGACP3ANPEPLAP3 | |
| SCHEMBL8620141 | 0.88 | PPARG (0.46) | PPARAPPARGACP3ANPEPLAP3 | |
| SCHEMBL8619979 | 0.88 | PPARG (0.49) | PPARAPPARGACP3ANPEPLAP3 | |
| SCHEMBL8625334 | 0.87 | PPARG (0.53) | PPARAPPARG | |
| SCHEMBL8620802 | 0.85 | PPARG (0.42) | PPARAPPARG | |
| SCHEMBL8621703 | 0.85 | PPARG (0.51) | PPARAPPARGACP3ANPEPLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | claimed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | claimed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | claimed |
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |