SCHEMBL8619941

SCHEMBL8619941

Cn1nc(-c2c(F)ccc(C=O)c2Cl)c(Cl)c1OC(F)F

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.33
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9098434 0.83 USP2 (0.33)
SCHEMBL7162428 0.78
SCHEMBL7707669 0.76 KCNH2 (0.34) SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL9081642 0.75 DRD1 (0.35) SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL7841255 0.75
SCHEMBL7906751 0.73 CYP1A2 (0.31) SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL6295365 0.73 HSD11B1 (0.36) SMN1; SMN2CYP2C9CYP2C19
SCHEMBL7707584 0.72 KDM4E (0.38) SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL9234573 0.72 DGAT2 (0.34) SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL9717776 0.71 WEE1 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0443059-B1 3-(Substituted phenyl)pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO LTD (JP) 1998-06-17 EP disclosed
EP-0361114-B1 3-(Substituted phenyl) pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO LTD (JP) 1998-06-03 EP disclosed
EP-0443059-A1 3-(Substituted phenyl)pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO., LTD. (JP) 1991-08-28 EP disclosed
US-5032165-A 3-(substituted phenyl)pyrazole derivatives, salts thereof, and herbicides therefrom NIHON NOHYAKU COMPANY, LTD. (JP) 1991-07-16 US disclosed
EP-0361114-A1 3-(Substituted phenyl) pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO., LTD. (JP) 1990-04-04 EP disclosed