Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618718 | 1.00 | P2RX7 (0.45) | P2RX7KCNA5TRPV1ROCK2ROCK1 | |
| SCHEMBL7359995 | 1.00 | P2RX7 (0.45) | P2RX7KCNA5TRPV1ROCK2ROCK1 | |
| SCHEMBL8620712 | 0.88 | MEN1 (0.42) | P2RX7KCNA5TRPV1ROCK2ROCK1 | |
| SCHEMBL8620709 | 0.88 | MEN1 (0.42) | P2RX7KCNA5TRPV1ROCK2ROCK1 | |
| SCHEMBL8620720 | 0.88 | MEN1 (0.42) | P2RX7KCNA5TRPV1ROCK2ROCK1 | |
| SCHEMBL8620009 | 0.80 | QPCT (0.39) | TRPV1ROCK2ROCK1 | |
| SCHEMBL7424824 | 0.80 | QPCT (0.39) | TRPV1ROCK2ROCK1 | |
| SCHEMBL8622425 | 0.80 | QPCT (0.39) | TRPV1ROCK2ROCK1 | |
| SCHEMBL8775014 | 0.79 | KMT2A (0.47) | TRPV1ROCK2ROCK1 | |
| SCHEMBL7356810 | 0.79 | KMT2A (0.47) | TRPV1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |