Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.63 |
| ▸ | CACNA1B | Q00975 | 7/20 | 0.63 |
| ▸ | CACNB1 | Q02641 | 7/20 | 0.63 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.63 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.59 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.59 |
| ▸ | CNR1 | P21554 | 8/20 | 0.51 |
| ▸ | CNR2 | P34972 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4243353 | 0.92 | OPRM1 (0.68) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL7280359 | 0.82 | CHRM2 (0.64) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL2430848 | 0.81 | MEN1 (0.69) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL9254374 | 0.81 | OPRM1 (0.59) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL2430851 | 0.81 | MEN1 (0.69) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL7267500 | 0.80 | CHRM2 (0.71) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL11386919 | 0.78 | OPRM1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL5266144 | 0.78 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL3396514 | 0.77 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL9258075 | 0.76 | OPRM1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723463-A | Pyrido 3,2-E!pyrazinones with anti-asthmatic action and processes for their manufacture | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1998-03-03 | — | — | US | claimed |