SCHEMBL8620153

SCHEMBL8620153

c1ccc(Nc2cccc(-c3ccc(-c4ccccc4)cc3)c2Nc2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 6/20 0.48
MEN1 O00255 5/20 0.48
MAPT P10636 5/20 0.48
KMT2A Q03164 5/20 0.48
KDM4E B2RXH2 4/20 0.48
GAA P10253 4/20 0.48
GLA P06280 2/20 0.48
RECQL P46063 1/20 0.48
ALDH1A1 P00352 8/20 0.47
LMNA P02545 3/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HSD17B10 Q99714 4/20 0.44
TSHR P16473 3/20 0.44
ALOX15 P16050 3/20 0.44
CYP3A4 P08684 3/20 0.44
HPGD P15428 2/20 0.44
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6077288 0.96 MAPT (0.52) TDP1MEN1MAPTKMT2AKDM4E
SCHEMBL30350962 0.96 MAPT (0.52) TDP1MEN1MAPTKMT2AKDM4E
SCHEMBL29742675 0.84 MAPT (0.56) TDP1MEN1MAPTKMT2AKDM4E
SCHEMBL17733477 0.84 FABP4 (0.52) TDP1MEN1MAPTKMT2AKDM4E
SCHEMBL5373697 0.84 MAPT (0.50) TDP1MEN1MAPTKMT2AKDM4E
SCHEMBL15661468 0.84 ALDH1A1 (0.44) TDP1MEN1MAPTKMT2AALDH1A1
SCHEMBL26101517 0.84 HSD17B10 (0.50) TDP1MEN1MAPTKMT2AKDM4E
SCHEMBL21046684 0.82 ALDH1A1 (0.47) TDP1MEN1MAPTKMT2AKDM4E
SCHEMBL19152233 0.81 ALDH1A1 (0.52) TDP1MEN1MAPTKMT2AKDM4E
Diphenylamine SCHEMBL15104438 0.81 ALDH1A1 (0.52) TDP1MEN1MAPTKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0452681-B1 Electrostatographic imaging member containing polyarylamine polymers XEROX CORP (US) 1998-06-03 EP disclosed
EP-0452682-B1 Polyarylamine polymers XEROX CORP (US) 1997-09-17 EP disclosed
US-5356743-A Electrophotographic imaging members containing polyarylamine polyesters XEROX CORPORATION (US) 1994-10-18 US disclosed
EP-0295113-B1 Polyarylamine compounds XEROX CORP (US) 1994-02-02 EP disclosed
US-5283143-A Electrophotographic imaging member containing arylamine terpolymers with CF3 substituted moieties XEROX CORPORATION (US) 1994-02-01 US disclosed
US-5262512-A Polyarylamine polyesters XEROX CORPORATION (US) 1993-11-16 US disclosed
US-5202408-A Arylamine containing terpolymers with CF3 substituted moieties XEROX CORPORATION (US) 1993-04-13 US disclosed
US-5155200-A Polyurethanes from dihydroxyarylamine compounds XEROX CORPORATION (US) 1992-10-13 US disclosed
EP-0452682-A2 Polyarylamine polymers XEROX CORPORATION (US) 1991-10-23 EP disclosed
EP-0452681-A2 Systems utilizing polyarylamine polymers XEROX CORPORATION (US) 1991-10-23 EP disclosed
US-5030532-A Electrophotographic imaging member utilizing polyarylamine polymers XEROX CORPORATION (US) 1991-07-09 US disclosed
US-4801517-A Polyarylamine compounds and systems utilizing polyarylamine compounds XEROX CORPORATION (US) 1989-01-31 US disclosed
EP-0295113-A2 Polyarylamine compounds XEROX CORPORATION (US) 1988-12-14 EP disclosed