Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 16/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 13/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 10/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 9/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SHBG | P04278 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625399 | 0.88 | POLB (0.42) | S1PR1S1PR3S1PR2S1PR4KDM4E | |
| SCHEMBL8618660 | 0.83 | POLB (0.42) | KDM4EALDH1A1LMNA | |
| SCHEMBL8620506 | 0.81 | S1PR1 (0.50) | S1PR1S1PR3S1PR2S1PR4ENPP2 | |
| SCHEMBL8624041 | 0.81 | FDFT1 (0.45) | S1PR1 | |
| SCHEMBL8947010 | 0.78 | S1PR1 (0.36) | S1PR1S1PR3S1PR2S1PR4S1PR5 | |
| SCHEMBL8619659 | 0.78 | EPHX2 (0.38) | — | |
| SCHEMBL8659011 | 0.72 | FDFT1 (0.56) | S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL8620192 | 0.70 | FDFT1 (0.43) | S1PR1S1PR3S1PR2S1PR4S1PR5 | |
| SCHEMBL8619754 | 0.70 | FDFT1 (0.50) | S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL8620898 | 0.70 | ENPP2 (0.60) | S1PR1S1PR3S1PR2S1PR4ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |