Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26529166 | 0.88 | MAPT (0.43) | MAPTGAAKDM4ELMNAHTT | |
| SCHEMBL6842000 | 0.79 | MAPT (0.43) | MAPTGAAKDM4ELMNAHTT | |
| SCHEMBL8623539 | 0.79 | ALDH1A1 (0.50) | MAPTLMNAHTTNPSR1POLB | |
| SCHEMBL2249641 | 0.77 | HTT (0.49) | MAPTGAALMNAHTTPOLB | |
| SCHEMBL7154811 | 0.76 | MAPT (0.50) | MAPTGAALMNAHTTNPSR1 | |
| SCHEMBL2247139 | 0.75 | HTT (0.48) | MAPTGAALMNAHTTPOLB | |
| SCHEMBL9362588 | 0.74 | ALDH1A1 (0.38) | MAPTGAAKDM4ELMNAHTT | |
| SCHEMBL5203453 | 0.74 | GAA (0.56) | MAPTGAAKDM4ELMNAHTT | |
| SCHEMBL28836799 | 0.74 | GPR35 (0.55) | MAPTGAAKDM4ELMNAHTT | |
| SCHEMBL2246833 | 0.74 | HTT (0.49) | MAPTGAALMNAHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849744-A | Pyrrolyl tetrahydrobenzoquinoxaline diones, their preparation and use as glutamate receptor antagonist | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |