Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626455 | 0.84 | IDO1 (0.35) | CRBNGAAIDO1EPHX2RIPK1 | |
| SCHEMBL8329105 | 0.83 | PYGL (0.47) | EPHX2RIPK1 | |
| SCHEMBL9025748 | 0.83 | PYGL (0.47) | EPHX2RIPK1 | |
| SCHEMBL9024163 | 0.80 | SCN9A (0.39) | RIPK1SCN9A | |
| SCHEMBL9025845 | 0.80 | RIPK1 (0.46) | RIPK1SCN9A | |
| SCHEMBL9025611 | 0.80 | PYGL (0.36) | CRBNEPHX2RIPK1DDB1SCN9A | |
| SCHEMBL9025399 | 0.80 | CRBN (0.38) | CRBNIDO1EPHX2RIPK1DDB1 | |
| SCHEMBL9024887 | 0.80 | RIPK1 (0.40) | RIPK1SCN9A | |
| SCHEMBL9023873 | 0.79 | RIPK1 (0.41) | CRBNRIPK1 | |
| SCHEMBL9024217 | 0.79 | RIPK1 (0.41) | CRBNRIPK1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789587-A | Heterocyclic-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1998-08-04 | — | — | US | disclosed |
| US-5606054-A | Heterocyclic-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1997-02-25 | — | — | US | disclosed |
| WO-1995016692-A1 | HETEROCYCLIC-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-06-22 | — | — | WO | disclosed |