Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215543 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1ALOX5APFEN1HSD11B1 | |
| Sulfamide SCHEMBL4639024 | 0.82 | PTGS2 (0.45) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL214628 | 0.79 | PTGS2 (0.56) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL2568289 | 0.78 | PTGS2 (0.68) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| Hydrochloric Acid SCHEMBL5794623 | 0.77 | PTGS2 (0.66) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| SCHEMBL8657273 | 0.76 | PTGS2 (0.69) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| SCHEMBL5668728 | 0.75 | PTGS1 (0.41) | PTGS2PTGS1ALDH1A1GAA | |
| SCHEMBL8658158 | 0.74 | PTGS2 (0.53) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| SCHEMBL8974740 | 0.72 | CA1 (0.41) | PTGS2PTGS1CA1CA2CA4 | |
| SCHEMBL851339 | 0.71 | PTGS2 (0.71) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998016227-A9 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA | — | 1998-07-30 | — | — | WO | claimed |