Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.69 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.47 |
| ▸ | FEN1 | P39748 | 4/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2568289 | 0.93 | PTGS2 (0.68) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| Hydrochloric Acid SCHEMBL5794623 | 0.91 | PTGS2 (0.66) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| SCHEMBL8661267 | 0.87 | PTGS2 (0.64) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| SCHEMBL8871414 | 0.85 | PTGS2 (0.65) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| SCHEMBL8659843 | 0.85 | CA2 (0.48) | PTGS2PTGS1ALOX5APFEN1CA1 | |
| SCHEMBL8661644 | 0.84 | PTGS1 (0.49) | PTGS2PTGS1ALOX5APFEN1TRPV1 | |
| SCHEMBL8661306 | 0.84 | CA1 (0.48) | PTGS2PTGS1ALOX5APFEN1CA1 | |
| SCHEMBL8350056 | 0.82 | CA1 (0.54) | PTGS2PTGS1ALOX5APFEN1CA1 | |
| SCHEMBL8347239 | 0.82 | CA2 (0.58) | ALOX5APFEN1CA1CA2CA4 | |
| SCHEMBL8659816 | 0.82 | CA2 (0.50) | PTGS2PTGS1ALOX5APFEN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | claimed |
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |
| EP-0794942-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016934-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-06-06 | — | — | WO | disclosed |