Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.46 |
| ▸ | EDNRB | P24530 | 3/20 | 0.46 |
| ▸ | FABP7 | O15540 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.45 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623773 | 0.92 | EDNRB (0.50) | EDNRAEDNRB | |
| SCHEMBL7947118 | 0.89 | SCN9A (0.44) | — | |
| SCHEMBL7531670 | 0.86 | FABP7 (0.49) | EDNRAEDNRBFABP7FABP3FABP5 | |
| SCHEMBL8620562 | 0.85 | FABP7 (0.52) | EDNRAEDNRBFABP7FABP3FABP5 | |
| SCHEMBL8625510 | 0.84 | EDNRB (0.43) | EDNRAEDNRB | |
| SCHEMBL8622123 | 0.83 | SCN9A (0.46) | EDNRAEDNRB | |
| SCHEMBL8678053 | 0.81 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL8621789 | 0.78 | ABCB1 (0.46) | EDNRAEDNRB | |
| SCHEMBL7531484 | 0.76 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL8620427 | 0.75 | EDNRA (0.43) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |