Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623769 | 0.91 | EDNRA (0.49) | ALDH1A1TDP1PRKCIPRKCZEDNRB | |
| SCHEMBL7947116 | 0.90 | ALDH1A1 (0.51) | ALDH1A1PRKCIPRKCZMGAMAMY1A | |
| SCHEMBL7531670 | 0.88 | FABP7 (0.49) | EDNRBEDNRA | |
| SCHEMBL8620561 | 0.85 | PRKCI (0.48) | ALDH1A1PRKCIPRKCZEDNRBEDNRA | |
| SCHEMBL8625505 | 0.84 | PRKCI (0.47) | ALDH1A1PRKCIPRKCZMGAMAMY1A | |
| SCHEMBL8622121 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TDP1PRKCIPRKCZMGAM | |
| SCHEMBL8678051 | 0.81 | EDNRA (0.52) | ALDH1A1EDNRBEDNRA | |
| SCHEMBL7531484 | 0.78 | EDNRA (0.56) | EDNRBEDNRA | |
| SCHEMBL8621791 | 0.78 | EDNRA (0.46) | EDNRBEDNRA | |
| SCHEMBL7534280 | 0.74 | PTGS2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |