Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | CFD | P00746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993529 | 0.84 | MRGPRX4 (0.52) | MRGPRX4CFDMAPK1ALDH1A1KDM4E | |
| SCHEMBL7257652 | 0.82 | MRGPRX4 (0.51) | MRGPRX4CFDMAPK1ALDH1A1KDM4E | |
| SCHEMBL6866159 | 0.81 | CFD (0.70) | MRGPRX4CFDALDH1A1KDM4EHPGD | |
| SCHEMBL30362215 | 0.77 | KMT2A (0.55) | MRGPRX4CFDMAPK1ALDH1A1KDM4E | |
| SCHEMBL15754099 | 0.77 | KMT2A (0.55) | MRGPRX4CFDMAPK1ALDH1A1KDM4E | |
| SCHEMBL12837926 | 0.77 | MRGPRX4 (0.57) | MRGPRX4CFDALDH1A1KDM4EHPGD | |
| SCHEMBL384685 | 0.77 | MRGPRX4 (0.57) | MRGPRX4CFDALDH1A1KDM4EHPGD | |
| SCHEMBL7597341 | 0.77 | MRGPRX4 (0.57) | MRGPRX4CFDALDH1A1KDM4EHPGD | |
| SCHEMBL31252031 | 0.75 | MRGPRX4 (0.59) | MRGPRX4CFDALDH1A1KDM4EHPGD | |
| SCHEMBL5453077 | 0.75 | MRGPRX4 (0.59) | MRGPRX4CFDALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874843-A1 | NOVEL SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPANES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997022604-A1 | NOVEL SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPANES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-06-26 | — | — | WO | disclosed |