SCHEMBL8622368

SCHEMBL8622368

O=C(NC1CCc2ccccc21)c1nccs1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 2/20 0.52
CNR2 P34972 2/20 0.52
P2RX7 Q99572 2/20 0.51
TAS1R3 Q7RTX0 5/20 0.50
TAS1R1 Q7RTX1 5/20 0.50
TAS1R2 Q8TE23 3/20 0.50
HTT P42858 1/20 0.50
ALDH1A1 P00352 3/20 0.49
TSHR P16473 1/20 0.49
ROCK2 O75116 2/20 0.48
ROCK1 Q13464 2/20 0.48
PDE2A O00408 1/20 0.48
PDE4A P27815 1/20 0.48
PDE4B Q07343 1/20 0.48
PDE4C Q08493 1/20 0.48
PDE4D Q08499 1/20 0.48
LMNA P02545 1/20 0.46
KMT2A Q03164 1/20 0.46
HPGDS O60760 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5122846 0.77 TAS1R3 (0.46) CNR1CNR2P2RX7TAS1R3TAS1R1
SCHEMBL2075961 0.77 TAS1R3 (0.55) CNR1CNR2TAS1R3TAS1R1TAS1R2
SCHEMBL3154101 0.76 SCN3A (0.56) HTTALDH1A1TSHRLMNAKMT2A
SCHEMBL6315251 0.76 RECQL (0.46) P2RX7TAS1R3TAS1R1TAS1R2ALDH1A1
SCHEMBL3460628 0.75 HTT (0.83) TAS1R3TAS1R1TAS1R2HTTALDH1A1
SCHEMBL3459886 0.75 HTT (0.83) TAS1R3TAS1R1TAS1R2HTTALDH1A1
SCHEMBL29742388 0.75 HTT (0.83) TAS1R3TAS1R1TAS1R2HTTALDH1A1
SCHEMBL2465110 0.75 HTT (0.83) TAS1R3TAS1R1TAS1R2HTTALDH1A1
SCHEMBL3421659 0.73 HTT (0.60) TAS1R3TAS1R1TAS1R2HTTALDH1A1
SCHEMBL1567171 0.73 PDPK1 (0.58) P2RX7TAS1R3TAS1R1TAS1R2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5728869-A Processes for the preparation of pesticides and intermediates AMERICAN CYANAMID COMPANY (US) 1998-03-17 US disclosed
US-5521317-A Processes for the preparation of pesticides and intermediates AMERICAN CYANAMID CO. (US) 1996-05-28 US disclosed
EP-0654464-A1 Processes for the preparation of pesticides and intermediates SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1995-05-24 EP disclosed