Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.52 |
| ▸ | EDNRB | P24530 | 12/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533979 | 0.94 | EDNRA (0.55) | EDNRAEDNRBMAOB | |
| SCHEMBL9543742 | 0.85 | EDNRA (0.49) | EDNRAEDNRB | |
| SCHEMBL7538071 | 0.80 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL8626015 | 0.80 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL8622694 | 0.79 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL7814457 | 0.79 | EDNRA (0.50) | EDNRAEDNRB | |
| SCHEMBL7531865 | 0.76 | PPARG (0.60) | EDNRAEDNRBMAOB | |
| SCHEMBL8626955 | 0.75 | CYP3A4 (0.42) | EDNRAEDNRB | |
| SCHEMBL8627743 | 0.74 | EDNRA (0.40) | EDNRAEDNRB | |
| SCHEMBL3572757 | 0.73 | PPARG (0.50) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |