Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.49 |
| ▸ | EDNRB | P24530 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814457 | 0.94 | EDNRA (0.50) | EDNRAEDNRBPPARG | |
| SCHEMBL8626955 | 0.90 | CYP3A4 (0.42) | EDNRAEDNRB | |
| SCHEMBL8622689 | 0.85 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL6953835 | 0.84 | EDNRA (0.45) | EDNRAEDNRB | |
| SCHEMBL9543747 | 0.84 | EDNRA (0.48) | EDNRAEDNRB | |
| SCHEMBL8476509 | 0.81 | EDNRA (0.47) | EDNRAEDNRB | |
| SCHEMBL8627743 | 0.79 | EDNRA (0.40) | EDNRAEDNRBPPARG | |
| SCHEMBL7533979 | 0.79 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL8087819 | 0.78 | EDNRA (0.37) | EDNRAEDNRB | |
| SCHEMBL7653814 | 0.75 | EDNRA (0.41) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993008799-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-13 | — | — | WO | disclosed |