SCHEMBL8622849

SCHEMBL8622849

CC(C)C1(C(C)C)CCCC1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8624879 0.93 ALDH1A1 (0.33)
SCHEMBL8624073 0.84
SCHEMBL8619794 0.78 CYP19A1 (0.33)
SCHEMBL8622752 0.72 GRIN2D (0.35)
SCHEMBL9663044 0.71 ALDH1A1 (0.35)
SCHEMBL4759700 0.71 ALDH1A1 (0.35)
SCHEMBL20494599 0.70 MME (0.34)
SCHEMBL12194088 0.67
SCHEMBL11457549 0.65 GRIN1 (0.34)
SCHEMBL8619365 0.65 CYP19A1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170283434-A1 NK1 ANTAGONISTS OPKO HEALTH INC (US) 2017-10-05 US disclosed
US-9688693-B2 NK1 antagonists OPKO HEALTH, INC. (US) 2017-06-27 US disclosed
US-20140336158-A1 NK1 ANTAGONISTS TERSERA THERAPEUTICS LLC 2014-11-13 US disclosed
US-8796299-B2 NK1 antagonists OPKO HEALTH, INC. (US) 2014-08-05 US disclosed
US-20130023503-A1 NK1 ANTAGONISTS OPKO HEALTH, INC. (US) 2013-01-24 US disclosed
US-8273895-B2 NK1 antagonists OPKO HEALTH, INC. (US) 2012-09-25 US disclosed
US-20110098468-A1 NK1 ANTAGONISTS OPKO HEALTH, INC. (US) 2011-04-28 US disclosed
US-7902366-B2 NK1 antagonists OPKO HEALTH, INC. (US) 2011-03-08 US disclosed
US-20070208001-A1 Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same INCYTE CORPORATION 2007-09-06 US disclosed
CN-1047173-C Optically active beta-aminoalkoxyborane complexes NISSAN CHEMICAL IND LTD (JP) 1999-12-08 CN disclosed
US-5852221-A Optically active β-aminoalkoxyborane complex NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1998-12-22 US disclosed
US-5808098-A REDUCING AGENT FROM AMINOALCOHOL NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1998-09-15 US disclosed
EP-0680484-B1 OPTICALLY ACTIVE BETA-AMINOALKOXYBORANE COMPLEXES NISSAN CHEMICAL IND LTD (JP) 1998-08-19 EP disclosed
US-5786485-A REACTING OPTICALLY ACTIVE BETA-AMINOALCOHOL WITH BORANE REAGENT TO PRODUCE OPTICALLY ACTIVE BETA-AMINOALKOXYBORANE COMPLEX NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-07-28 US disclosed
US-5767277-A REDUCING AGENT FOR A CARBONYL COMPOUND TO PRODUCE A 1,3-SYN-DIOL COMPOUND NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1998-06-16 US disclosed
US-5739347-A REDUCING AGENTS FOR DECARBONYLATION NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1998-04-14 US disclosed
US-5663348-A REDUCTION OF DIKETONE WITH AMINOALKOXYBORANE COMPLEX TO FORM DIALCOHOL ESTER COMPOUND NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1997-09-02 US disclosed
CN-1116850-A Optically active beta-aminoalkoxyborane complexes NISSAN CHEMICAL IND LTD (JP) 1996-02-14 CN disclosed
EP-0680484-A1 OPTICALLY ACTIVE $g(b)-AMINOALKOXYBORANE COMPLEX NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1995-11-08 EP disclosed
WO-1994017079-A1 OPTICALLY ACTIVE β-AMINOALKOXYBORANE COMPLEX NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1994-08-04 WO disclosed