SCHEMBL8622853

SCHEMBL8622853

COc1ccc(Nc2ncccc2NS(=O)(=O)c2ccc(O)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 2/20 1.00
TUBB P07437 2/20 1.00
TUBA3C P0DPH7 2/20 1.00
TUBA1B P68363 2/20 1.00
TUBA4A P68366 2/20 1.00
TUBB4B P68371 2/20 1.00
TUBB3 Q13509 2/20 1.00
TUBB2A Q13885 2/20 1.00
TUBB8 Q3ZCM7 2/20 1.00
TUBA3E Q6PEY2 2/20 1.00
TUBA1A Q71U36 2/20 1.00
TUBA1C Q9BQE3 2/20 1.00
TUBB6 Q9BUF5 2/20 1.00
TUBB2B Q9BVA1 2/20 1.00
TUBB1 Q9H4B7 2/20 1.00
GLO1 Q04760 1/20 0.58
SLC40A1 Q9NP59 1/20 0.58
HTT P42858 2/20 0.54
LMNA P02545 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Abt-751 SCHEMBL5023335 1.00 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Abt-751 SCHEMBL29355261 1.00 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Abt-751 SCHEMBL111645 1.00 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Abt-751 SCHEMBL5016878 0.99 TUBB4A (0.98) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Abt-751 SCHEMBL5016898 0.96 TUBB4A (0.92) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL8625702 0.94 TUBB4A (0.89) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL8624355 0.91 TUBB4A (0.82) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL8629330 0.90 TUBB4A (0.81) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL8623536 0.90 TUBB4A (0.81) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL5692592 0.89 TUBB4A (0.80) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0472053-B1 Sulfonamide derivatives EISAI CO LTD (JP) 1998-06-17 EP disclosed
US-5610304-A Pyrimidinyl or pyridinyl sulfonamide substituted compounds EISAI CO., LTD. (JP) 1997-03-11 US disclosed
US-5610320-A ANTITUMOR AGENTS EISAI CO., LTD. (JP) 1997-03-11 US disclosed
US-5434172-A Antitumor EISAI CO., LTD. (JP) 1995-07-18 US disclosed
US-5332751-A Antitumor EISAI CO., LTD. (JP) 1994-07-26 US disclosed
US-5292758-A Sulfonamide derivatives EISAI CO., LTD. (JP) 1994-03-08 US disclosed
US-5250549-A Antitumor agents EISAI CO., LTD. (JP) 1993-10-05 US disclosed
EP-0472053-A2 Sulfonamide derivatives Eisai Co., Ltd. (JP) 1992-02-26 EP disclosed