Known targets — ChEMBL curated mechanism
TUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TUBB8B
The experimentally established mechanism targets of Abt-751. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A known ✓ | P04350 | 2/20 | 0.92 |
| ▸ | TUBB known ✓ | P07437 | 2/20 | 0.92 |
| ▸ | TUBB4B known ✓ | P68371 | 2/20 | 0.92 |
| ▸ | TUBB3 known ✓ | Q13509 | 2/20 | 0.92 |
| ▸ | TUBB2A known ✓ | Q13885 | 2/20 | 0.92 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 2/20 | 0.92 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 2/20 | 0.92 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 2/20 | 0.92 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 2/20 | 0.92 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.92 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.92 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.92 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.92 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.92 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.92 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622853 | 0.96 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Abt-751 SCHEMBL111645 | 0.96 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Abt-751 SCHEMBL5023335 | 0.96 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Abt-751 SCHEMBL29355261 | 0.96 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Abt-751 SCHEMBL5016878 | 0.95 | TUBB4A (0.98) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8625702 | 0.90 | TUBB4A (0.89) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5692592 | 0.89 | TUBB4A (0.80) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8624783 | 0.88 | TUBB4A (0.78) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8624796 | 0.87 | TUBB4A (0.80) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8624355 | 0.87 | TUBB4A (0.82) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021471-A1 | Crystalline N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide ethanolates | ABBOTT LABORATORIES | 2007-01-25 | — | — | US | claimed |
| US-7449584-B2 | N-(2((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide Crystalline Form 1 | ABBOTT LABORATORIES INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-7446206-B2 | N-((2Z)-2-((4-hydroxyphenyl) amino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide crystalline form 2 | ABBOTT LABORATORIES INC. (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1836170-A1 | N-((2Z)-2-((4-HYDROXYPHENYL)IMINO)-1,2-DIHYDRO-3-PYRIDINYL)-4-METHOXYBENZENESULFONAMIDE CRYSTALLINE FORM 2 | ABBOTT LABORATORIES (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20070099967-A1 | causing nucleation in mixture with solvent between about 60 degrees C. and 100 degrees C., supersaturated; and isolating Crystalline Form 1 | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070021471-A1 | Crystalline N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide ethanolates | ABBOTT LABORATORIES | 2007-01-25 | — | — | US | disclosed |
| US-20070004782-A1 | N-((2Z)-2-((4-Hydroxyphenyl) amino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide Crystalline Form 2 | ABBVIE INC. | 2007-01-04 | — | — | US | disclosed |
| WO-2006076630-A1 | N-((2Z)-2-((4-HYDROXYPHENYL)IMINO)-1,2-DIHYDRO-3-PYRIDINYL)-4-METHOXYBENZENESULFONAMIDE CRYSTALLINE FORM 2 | ABBOTT LABORATORIES (US) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006076511-A1 | N-(2-((4-HYDROXYPHENYL)AMINO)PYRIDIN-3-YL)-4-METHOXYBENZENESULFONAMIDE CRYSTALLINE FORM 1 | ABBOTT LABORATORIES (US) | 2006-07-20 | — | — | WO | disclosed |