Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 10/20 | 0.34 |
| ▸ | SCN2B | O60939 | 2/20 | 0.34 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.33 |
| ▸ | BRS3 | P32247 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10256117 | 0.85 | SCN9A (0.39) | ALDH1A1CYP1A2KDM4EHPGDSCN9A | |
| SCHEMBL10260725 | 0.84 | KDM4E (0.47) | ALDH1A1CYP1A2KDM4EHPGDSCN9A | |
| SCHEMBL862326 | 0.83 | CYP2C8 (0.38) | ALDH1A1CYP1A2KDM4EHPGDSCN9A | |
| SCHEMBL831565 | 0.82 | ALDH1A1 (0.40) | ALDH1A1CYP1A2KDM4EHPGDSCN9A | |
| SCHEMBL862139 | 0.81 | MAPK8 (0.35) | ALDH1A1CYP1A2KDM4EHPGDSCN9A | |
| SCHEMBL10256960 | 0.81 | CHRM1 (0.37) | ALDH1A1CYP1A2KDM4EHPGDCYP2C8 | |
| SCHEMBL862037 | 0.80 | KMT2A (0.44) | ALDH1A1CYP1A2KDM4EHPGDTSHR | |
| SCHEMBL831574 | 0.80 | KDM4E (0.41) | ALDH1A1CYP1A2KDM4EHPGDSCN9A | |
| SCHEMBL862363 | 0.80 | KMT2A (0.34) | ALDH1A1CYP1A2KDM4EHPGDSCN9A | |
| SCHEMBL10255118 | 0.80 | SCN9A (0.40) | ALDH1A1CYP1A2KDM4EHPGDSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | ALDH1A1 1792/4885CYP1A2 305/4885KDM4E 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.