Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 8/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073041 | 0.81 | ALDH1A1 (0.62) | LMNAHPGDALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL20194478 | 0.78 | POLB (0.64) | LMNAHPGDRAB9APOLBALDH1A1 | |
| SCHEMBL17667026 | 0.77 | ALDH1A1 (0.62) | LMNAHPGDRAB9APOLBALDH1A1 | |
| SCHEMBL17667024 | 0.77 | ALDH1A1 (0.62) | LMNAHPGDRAB9APOLBALDH1A1 | |
| SCHEMBL28226277 | 0.77 | HPGD (0.77) | LMNAHPGDRAB9APOLBALDH1A1 | |
| SCHEMBL2466017 | 0.77 | HPGD (0.58) | LMNAHPGDRAB9APOLBALDH1A1 | |
| SCHEMBL6668159 | 0.76 | POLB (0.62) | LMNAHPGDRAB9APOLBALDH1A1 | |
| SCHEMBL4071827 | 0.76 | ALDH1A1 (0.60) | LMNAALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL3561734 | 0.76 | POLB (0.70) | LMNAHPGDPOLBALDH1A1MAPT | |
| SCHEMBL7778409 | 0.75 | USP2 (0.69) | LMNAHPGDRAB9APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |