Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28226277 | 0.84 | HPGD (0.77) | USP2LMNAHPGDRAB9APOLB | |
| SCHEMBL13438260 | 0.82 | USP2 (0.93) | USP2LMNAHPGDPOLBMAPT | |
| SCHEMBL17205973 | 0.81 | USP2 (0.84) | USP2LMNAHPGDPOLBMAPT | |
| SCHEMBL1661081 | 0.80 | TRPV1 (0.76) | LMNAHPGDALDH1A1ALOX15TDP1 | |
| SCHEMBL8269659 | 0.80 | USP2 (0.76) | USP2HPGDRAB9APOLBMAPT | |
| SCHEMBL28179817 | 0.78 | USP2 (0.84) | USP2LMNAHPGDPOLBMAPT | |
| SCHEMBL9558084 | 0.78 | RAB9A (1.00) | LMNAHPGDRAB9APOLBALDH1A1 | |
| SCHEMBL6076909 | 0.78 | USP2 (0.73) | USP2LMNAHPGDPOLBMAPT | |
| SCHEMBL28999860 | 0.78 | SMN1; SMN2 (0.71) | USP2HPGDRAB9APOLBMAPT | |
| SCHEMBL5248141 | 0.77 | HPGD (0.74) | USP2LMNAHPGDRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129084-A2 | PPAR GAMMA LIGANDS | GLAXO GROUP LIMITED (GB) | 2001-09-05 | — | — | EP | claimed |
| WO-2000027832-A2 | THIAZOLE DERIVATIVES AS PPAR GAMMA LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-05-18 | — | — | WO | claimed |
| EP-1129084-A2 | PPAR GAMMA LIGANDS | GLAXO GROUP LIMITED (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027832-A2 | THIAZOLE DERIVATIVES AS PPAR GAMMA LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-05-18 | — | — | WO | disclosed |