Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 2/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81999 | 1.00 | LTA4H (0.56) | LTA4HEPHX2FFAR1HDAC2TDP1 | |
| SCHEMBL2162241 | 0.93 | HDAC2 (0.56) | LTA4HEPHX2FFAR1HDAC2TDP1 | |
| Biphenyl SCHEMBL27528312 | 0.93 | TDP1 (0.61) | LTA4HEPHX2FFAR1HDAC2TDP1 | |
| SCHEMBL5534575 | 0.91 | HDAC2 (0.57) | LTA4HEPHX2FFAR1HDAC2TDP1 | |
| SCHEMBL5540196 | 0.91 | HDAC2 (0.57) | LTA4HEPHX2FFAR1HDAC2TDP1 | |
| SCHEMBL3535251 | 0.91 | CA2 (0.54) | LTA4HEPHX2FFAR1TDP1CA2 | |
| SCHEMBL10001880 | 0.89 | MEN1 (0.53) | LTA4HEPHX2FFAR1HDAC2TDP1 | |
| SCHEMBL19730229 | 0.87 | MEN1 (0.46) | LTA4HEPHX2FFAR1HDAC2HDAC1 | |
| SCHEMBL22251662 | 0.86 | TDP1 (0.71) | FFAR1HDAC2TDP1MMP12ABCC4 | |
| SCHEMBL1938644 | 0.86 | TDP1 (0.71) | FFAR1HDAC2TDP1MMP12ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |