Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623149 | 0.85 | PNMT (0.46) | PNMTSLC6A2SLC6A3TAAR1CNR1 | |
| SCHEMBL8627137 | 0.85 | SLC6A2 (0.52) | PNMTSLC6A2SLC6A3ADRB2TAAR1 | |
| SCHEMBL200500 | 0.84 | SLC6A2 (0.56) | PNMTSLC6A2SLC6A3CNR1CNR2 | |
| SCHEMBL8622323 | 0.84 | TAAR1 (0.53) | PNMTSLC6A2SLC6A3TAAR1CNR1 | |
| Hydrochloric Acid SCHEMBL3374865 | 0.84 | SLC6A2 (0.50) | PNMTSLC6A2SLC6A3ADRB2TAAR1 | |
| SCHEMBL4691720 | 0.83 | SLC6A3 (0.62) | PNMTSLC6A2SLC6A3ADRB2CNR1 | |
| Hydrochloric Acid SCHEMBL3372120 | 0.83 | SLC6A2 (0.54) | PNMTSLC6A2SLC6A3CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL3371509 | 0.82 | SLC6A2 (0.60) | SLC6A2SLC6A3ADRB2CNR1CNR2 | |
| SCHEMBL8622251 | 0.81 | PNMT (0.60) | PNMTSLC6A2SLC6A3ADRB2TAAR1 | |
| SCHEMBL8618784 | 0.81 | HTR2A (0.58) | PNMTSLC6A2SLC6A3ADRB2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5777150-A | Substituted amic acid derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-07-07 | — | — | US | disclosed |
| EP-0611749-B1 | Substituted amic acid derivatives useful for treatment of arteriosclerosis | BANYU PHARMA CO LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| US-5616803-A | EXHIBIT SQUALENE SYNTHASE-INHIBITORY ACTIVITIES; USEFUL IN TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA, HYPERLIPEMIA AND ARTERIOSCLEROSIS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-04-01 | — | — | US | disclosed |
| US-5606101-A | INTERMEDIATES FOR SQUALENE SYNTHASE INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5488149-A | SQUALENE SYNTHASE INHIBITORS AS ANTICHOLESTEROL OR ANTILIPEMIC AGENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| EP-0611749-A1 | Substituted amic acid derivatives useful for treatment of arteriosclerosis | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-08-24 | — | — | EP | disclosed |