SCHEMBL8623895

SCHEMBL8623895

CO/C=C(/C(=O)O)c1cccc2ccc(Oc3nc(OC)cc(OC)n3)cc12

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CYP1A2 P05177 3/20 0.43
CYP2C9 P11712 3/20 0.43
CYP2C19 P33261 3/20 0.43
CYP3A4 P08684 2/20 0.43
ATM Q13315 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
GAA P10253 1/20 0.41
AKR1C2 P52895 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8601815 1.00 MTNR1A (0.44) MTNR1ASMN1; SMN2L3MBTL1CYP1A2CYP2C9
SCHEMBL8601819 1.00 MTNR1A (0.44) MTNR1ASMN1; SMN2L3MBTL1CYP1A2CYP2C9
SCHEMBL8659243 0.91 MTNR1A (0.45) MTNR1ASMN1; SMN2L3MBTL1CYP1A2CYP2C9
SCHEMBL8601175 0.80 MTNR1A (0.50) MTNR1ASMN1; SMN2L3MBTL1CYP1A2CYP2C9
SCHEMBL8631166 0.76 MTNR1A (0.48) MTNR1AAKR1C2
SCHEMBL8631167 0.76 MTNR1A (0.48) MTNR1AAKR1C2
SCHEMBL8891576 0.76 AKR1C2 (0.46) MTNR1ASMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL8891560 0.76 AKR1C2 (0.46) MTNR1ASMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL8598935 0.76 AKR1C2 (0.46) MTNR1ACYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL8598938 0.76 AKR1C2 (0.46) MTNR1ACYP1A2CYP2C9CYP2C19CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0819111-A1 FUNGICIDAL COMPOUNDS AgrEvo UK Limited (GB) 1998-01-21 EP disclosed
WO-1996029301-A1 FUNGICIDAL COMPOUNDS AGREVO UK LIMITED (GB) 1996-09-26 WO disclosed