Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 13/20 | 0.47 |
| ▸ | ADRA2B known ✓ | P18089 | 13/20 | 0.47 |
| ▸ | ADRA2C known ✓ | P18825 | 13/20 | 0.47 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.40 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.40 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.40 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.76 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.70 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.70 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5677296 | 0.98 | CXCR4 (0.79) | CXCR4APOBEC3AAPOBEC3GADRA2AADRA2B | |
| SCHEMBL12132035 | 0.87 | CXCR4 (0.66) | CXCR4APOBEC3AAPOBEC3GADRA2AADRA2B | |
| SCHEMBL6301909 | 0.86 | CXCR4 (0.75) | CXCR4APOBEC3AAPOBEC3GADRA2AADRA2B | |
| SCHEMBL12966337 | 0.85 | — | — | |
| SCHEMBL13512431 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL7541441 | 0.84 | CXCR4 (0.72) | CXCR4APOBEC3AAPOBEC3GADRA2AADRA2B | |
| SCHEMBL12145482 | 0.81 | CXCR4 (0.63) | CXCR4APOBEC3AAPOBEC3GADRA2AADRA2B | |
| SCHEMBL2492454 | 0.81 | CXCR4 (0.75) | CXCR4APOBEC3AAPOBEC3GADRA2AADRA2B | |
| SCHEMBL13509984 | 0.81 | CXCR4 (0.63) | CXCR4APOBEC3AAPOBEC3GADRA2AADRA2B | |
| SCHEMBL25213248 | 0.81 | APOBEC3A (0.59) | CXCR4APOBEC3AAPOBEC3GADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708086-B1 | Bisguanidine salts and a method for releasing a base using the same salts | FUJI PHOTO FILM CO LTD (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5728879-A | HEAT SENSITIVE ELEMENTS FOR RECORDING AND FORMING IMAGES | FUJI PHOTO FILM CO., LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0708086-A1 | Bisguanidine salts and a method for releasing a base using the same salts | FUJI PHOTO FILM CO., LTD. (JP) | 1996-04-24 | — | — | EP | disclosed |