Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132822 | 0.79 | KDM4E (0.57) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL30660068 | 0.79 | KDM4E (0.57) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL29132823 | 0.79 | KDM4E (0.57) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL2427953 | 0.76 | GAA (0.52) | MEN1KMT2AL3MBTL1ALDH1A1MMP9 | |
| SCHEMBL11360473 | 0.76 | ALDH1A1 (0.47) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7855163 | 0.76 | MMP2 (0.43) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7605696 | 0.76 | MMP2 (0.49) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7265100 | 0.75 | ALDH1A1 (0.56) | MEN1KMT2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL7272751 | 0.75 | ALDH1A1 (0.56) | MEN1KMT2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL4955422 | 0.72 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792858-A | ACYLATING LYSOSPHINGOLIPIDS AND THEIR DERIVATIVES WITH AN ALIPHATIC ACID HAVING 2 TO 24 CARBON ATOMS, SUBSTITUTED BY ONE OR MORE POLAR GROUPS; PROTEIN-KINASE INHIBITOR, USEFUL FOR NERVOUS SYSTEM DISORDER TREATMENT | FIDIA S.P.A. (IT) | 1998-08-11 | — | — | US | disclosed |
| EP-0373038-B1 | New lysosphingolipid derivatives | FIDIA SPA (IT) | 1997-03-05 | — | — | EP | disclosed |
| US-5519007-A | ENZYME INHIBITORS OF KINASES FOR NERVOUS SYSTEM INHIBITORS | FIDIA, S.P.A. (IT) | 1996-05-21 | — | — | US | disclosed |