Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625407 | 0.88 | SYK (0.55) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL6190711 | 0.82 | SYK (0.69) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL12301166 | 0.80 | SYK (0.62) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL6187792 | 0.76 | ALDH1A1 (0.54) | SYK | |
| SCHEMBL2760114 | 0.75 | SYK (0.61) | SYKAURKBINCENPEGFRERBB2 | |
| SCHEMBL2250667 | 0.74 | SYK (0.52) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL1406446 | 0.73 | SYK (0.65) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL21835286 | 0.72 | SYK (0.50) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL15701533 | 0.72 | MRGPRX4 (0.52) | SYKAURKBINCENPEGFRERBB2 | |
| SCHEMBL26580976 | 0.71 | KDM4E (0.51) | SYKAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880507-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1997030034-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |