Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 10/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | SMO | Q99835 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28153213 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA | |
| SCHEMBL9719851 | 0.82 | MAOA (0.48) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA | |
| SCHEMBL27557523 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA | |
| SCHEMBL9719816 | 0.81 | MAPT (0.53) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA | |
| SCHEMBL28025324 | 0.81 | SYK (0.59) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA | |
| SCHEMBL169753 | 0.79 | SMN1; SMN2 (0.63) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA | |
| SCHEMBL16485526 | 0.79 | PARP10 (0.49) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA | |
| SCHEMBL13645800 | 0.78 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2MAOASYK | |
| SCHEMBL20526953 | 0.78 | PARP10 (0.51) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA | |
| SCHEMBL27299169 | 0.78 | FFAR1 (0.53) | KDM4EALDH1A1SMN1; SMN2PARP10MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885ALDH1A1 2556/4885SMN1; SMN2 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.