Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055102 | 0.98 | PTGS2 (0.64) | PTGS2PTGS1ABCB11ALDH1A1 | |
| Benzenesulfonamide SCHEMBL7641687 | 0.95 | PTGS2 (0.70) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL7926014 | 0.88 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL8525009 | 0.88 | PTGS2 (0.65) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8637047 | 0.88 | PTGS2 (0.63) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL7928751 | 0.87 | PTGS2 (0.66) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8688532 | 0.87 | PTGS2 (0.57) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8692480 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8165901 | 0.86 | PTGS2 (0.62) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8635925 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998016227-A9 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA | — | 1998-07-30 | — | — | WO | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |