Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.52 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623294 | 0.84 | LPAR1 (0.49) | LPAR1LPAR5FFAR1MAPK14ALDH1A1 | |
| SCHEMBL1746823 | 0.83 | LTA4H (0.60) | LPAR1LPAR5LTA4HFFAR1MAPK14 | |
| SCHEMBL27871822 | 0.83 | LPAR1 (0.48) | LPAR1LPAR5MAPK14ALDH1A1 | |
| SCHEMBL2914999 | 0.80 | F2 (0.43) | — | |
| SCHEMBL18240129 | 0.79 | LTA4H (0.66) | LTA4HEPHX2FFAR1PPARAALDH1A1 | |
| SCHEMBL30657231 | 0.79 | LTA4H (0.43) | LPAR1LPAR5LTA4HEPHX2PPARA | |
| SCHEMBL26636357 | 0.79 | LTA4H (0.43) | LPAR1LPAR5LTA4HEPHX2PPARA | |
| 1,4-Butanediol SCHEMBL28726461 | 0.79 | MEN1 (0.50) | ALDH1A1CYP1A2CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL28862098 | 0.78 | LTA4H (0.58) | LTA4HEPHX2FFAR1PPARAALDH1A1 | |
| SCHEMBL7690257 | 0.78 | ALDH1A1 (0.59) | LPAR1LPAR5LTA4HMAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |