Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | DTYMK | P23919 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | PPOX | P50336 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381314 | 0.89 | MAPT (0.56) | MAPTALDH1A1LMNAPLA2G4BKDM4E | |
| SCHEMBL2155062 | 0.87 | MAPT (0.63) | MAPTALDH1A1LMNAPLA2G4BKDM4E | |
| SCHEMBL8872227 | 0.86 | MAPT (0.61) | MAPTALDH1A1LMNAKDM4EDTYMK | |
| SCHEMBL8628560 | 0.86 | PTPN11 (0.60) | MAPTPLA2G4BAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8699678 | 0.84 | MAPT (0.43) | MAPTALDH1A1LMNAPLA2G4BKDM4E | |
| SCHEMBL28528554 | 0.83 | KDM4E (0.49) | MAPTALDH1A1LMNAKDM4EDTYMK | |
| SCHEMBL30686065 | 0.83 | KDM4E (0.49) | MAPTALDH1A1LMNAKDM4EDTYMK | |
| SCHEMBL8633004 | 0.83 | MAPT (0.42) | MAPTALDH1A1LMNAPLA2G4BKDM4E | |
| SCHEMBL1749050 | 0.79 | PLA2G4B (0.53) | MAPTALDH1A1LMNAPLA2G4BKMT2A | |
| SCHEMBL26343197 | 0.79 | DTYMK (0.50) | MAPTALDH1A1LMNAKDM4EDTYMK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |