Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.60 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 3/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381314 | 0.96 | MAPT (0.56) | PTPN11PLA2G4BMAPTAKR1C3AKR1C2 | |
| SCHEMBL2155062 | 0.91 | MAPT (0.63) | PTPN11PLA2G4BMAPTAKR1C3AKR1C2 | |
| SCHEMBL8625655 | 0.86 | MAPT (0.48) | PTPN11PLA2G4BMAPTRARBAKR1C3 | |
| SCHEMBL1749050 | 0.85 | PLA2G4B (0.53) | PTPN11PLA2G4BTP53TSHRMAPT | |
| SCHEMBL8872227 | 0.85 | MAPT (0.61) | TP53TSHRMAPT | |
| SCHEMBL8629258 | 0.84 | PLA2G4B (0.51) | PTPN11PLA2G4BTP53TSHRMAPT | |
| SCHEMBL10681005 | 0.84 | MAPT (0.58) | PLA2G4BMAPTAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6565647 | 0.84 | MAPT (0.55) | PTPN11PLA2G4BMAPTAKR1C3AKR1C2 | |
| SCHEMBL28528554 | 0.84 | KDM4E (0.49) | TSHRMAPTAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL30686065 | 0.84 | KDM4E (0.49) | TSHRMAPTAKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |