Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21784764 | 0.80 | TSHR (0.39) | PDE10ACYP3A4KAT2BBAZ2BTSHR | |
| SCHEMBL21780570 | 0.77 | SLC6A3 (0.39) | PDE10ACYP3A4KAT2BBAZ2BTSHR | |
| SCHEMBL10334674 | 0.77 | GBA1 (0.41) | ADRA2AADRA2BADRA2CGBA1HCRTR2 | |
| SCHEMBL10335608 | 0.75 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CGBA1HCRTR2 | |
| SCHEMBL16234728 | 0.74 | ADRA2A (0.38) | PDE10AADRA2AADRA2BADRA2CGBA1 | |
| SCHEMBL22156257 | 0.74 | ADRA2A (0.39) | PDE10ACYP3A4ADRA2AADRA2BADRA2C | |
| SCHEMBL22152594 | 0.69 | ADRA2A (0.36) | PDE10AADRA2AADRA2BADRA2CKAT2B | |
| SCHEMBL18721784 | 0.68 | KAT2B (0.40) | PDE10ACYP3A4KAT2BBAZ2BTSHR | |
| SCHEMBL18197670 | 0.65 | KAT2B (0.43) | PDE10AKAT2BBAZ2B | |
| SCHEMBL28068627 | 0.65 | TSHR (0.39) | ADRA2AADRA2BADRA2CGBA1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828736-A1 | SUBSTITUTED SULFONYLPHENYLHETEROCYCLES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038442-A1 | SUBSTITUTED SULFONYLPHENYLHETEROCYCLES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |