Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.57 |
| ▸ | SQLE | Q14534 | 4/20 | 0.57 |
| ▸ | FNTA | P49354 | 1/20 | 0.53 |
| ▸ | FNTB | P49356 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819963 | 1.00 | KMT2A (0.64) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL18092234 | 1.00 | KMT2A (0.64) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL8626072 | 1.00 | KMT2A (0.64) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL9189400 | 0.90 | KMT2A (0.68) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL9189396 | 0.90 | KMT2A (0.68) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL24092723 | 0.87 | KMT2A (0.77) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL18705403 | 0.87 | KMT2A (0.77) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL9138262 | 0.87 | KMT2A (0.77) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL9159020 | 0.87 | KMT2A (0.77) | KMT2AMAPTALDH1A1MEN1CYP3A4 | |
| SCHEMBL9137864 | 0.87 | KMT2A (0.77) | KMT2AMAPTALDH1A1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0601573-A1 | Alpha-phosphonocarboxylate squalene synthetase inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5312814-A | Antilipemic agents or anticholesterol agents | BRISTOL-MYERS SQUIBB CO. (US) | 1994-05-17 | — | — | US | disclosed |