SCHEMBL8626307

SCHEMBL8626307

Nc1ccc(N)c2c[nH]cc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.40
TDP1 Q9NUW8 4/20 0.40
ALDH1A1 P00352 3/20 0.40
HPGD P15428 3/20 0.40
TSHR P16473 2/20 0.40
HSD17B10 Q99714 2/20 0.40
EP300 Q09472 3/20 0.36
KAT8 Q9H7Z6 3/20 0.36
IDO1 P14902 2/20 0.36
KAT2B Q92831 2/20 0.36
HDAC3 O15379 1/20 0.36
NCOR2 Q9Y618 1/20 0.36
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
KEAP1 Q14145 3/20 0.34
NFE2L2 Q16236 2/20 0.34
USP2 O75604 2/20 0.34
ATM Q13315 1/20 0.34
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL201893 0.65 ALDH1A1 (0.73) CYP3A4TDP1ALDH1A1HPGDTSHR
Hydrochloric Acid SCHEMBL7191297 0.62 CYP3A4 (0.69) CYP3A4TDP1ALDH1A1HPGDTSHR
SCHEMBL31057998 0.62 ALDH1A1 (0.40) CYP3A4TDP1ALDH1A1HPGDTSHR
SCHEMBL1864447 0.62 ALDH1A1 (0.40) CYP3A4TDP1ALDH1A1HPGDTSHR
SCHEMBL23637789 0.60 ALDH1A1 (0.40) CYP3A4TDP1ALDH1A1HPGDTSHR
SCHEMBL20298586 0.60 ALDH1A1 (0.45) TDP1ALDH1A1HPGDTSHRHSD17B10
SCHEMBL21854609 0.60 ALDH1A1 (0.87) CYP3A4TDP1ALDH1A1HPGDTSHR
SCHEMBL866016 0.58 KEAP1 (0.42) CYP3A4TDP1ALDH1A1HPGDTSHR
SCHEMBL867279 0.58 KEAP1 (0.42) CYP3A4TDP1ALDH1A1HPGDTSHR
SCHEMBL476877 0.58

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0614915-B1 Polymer scale preventive agent SHINETSU CHEMICAL CO (JP) 1998-06-24 EP disclosed
US-5420214-A Process to prevent scale adhesion using condensation product of a diamino heterocyclic and a quinone SHIN-ETSU CHEMICAL CO., LTD. (JP) 1995-05-30 US disclosed
EP-0614915-A1 Polymer scale preventive agent Shin-Etsu Chemical Co., Ltd. (JP) 1994-09-14 EP disclosed