Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.66 |
| ▸ | CYP1B1 | Q16678 | 14/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | OGA | O60502 | 1/20 | 0.58 |
| ▸ | HEXA | P06865 | 1/20 | 0.58 |
| ▸ | HEXB | P07686 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10262127 | 0.96 | CYP1B1 (0.67) | SIRT1CYP1B1ALDH1A1POLBKDM4E | |
| SCHEMBL12660579 | 0.91 | CYP1B1 (0.67) | SIRT1CYP1B1ALDH1A1POLBKDM4E | |
| SCHEMBL12660542 | 0.84 | SIRT1 (0.66) | SIRT1CYP1B1ALDH1A1POLBKDM4E | |
| SCHEMBL8395399 | 0.84 | SIRT1 (0.66) | SIRT1CYP1B1ALDH1A1POLBMEN1 | |
| SCHEMBL8395338 | 0.84 | SIRT1 (0.66) | SIRT1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL26243132 | 0.81 | CYP1B1 (0.70) | CYP1B1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL12660424 | 0.81 | MEN1 (0.56) | CYP1B1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL3773566 | 0.81 | POLB (0.74) | CYP1B1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL7328383 | 0.81 | CYP1B1 (0.65) | CYP1B1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL30499259 | 0.81 | POLB (0.74) | CYP1B1ALDH1A1POLBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714387-B1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AG (DE) | 1998-05-27 | — | — | EP | disclosed |
| EP-0714387-A1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AKTIENGESELLSCHAFT (DE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005365-A1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AKTIENGESELLSCHAFT (DE) | 1995-02-23 | — | — | WO | disclosed |