Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629803 | 0.80 | CYP3A4 (0.39) | KEAP1NFE2L2CA12CA9CA1 | |
| SCHEMBL8561528 | 0.70 | GRIA2 (0.50) | CA12CA9CA1CA2CA14 | |
| SCHEMBL8623980 | 0.69 | GRIA2 (0.47) | CA12CA9CA1CA2CA14 | |
| SCHEMBL18186896 | 0.68 | PIK3CD (0.39) | CA12CA9CA1CA2CA14 | |
| SCHEMBL12601151 | 0.67 | CACNA1H (0.34) | KEAP1NFE2L2CYP3A4 | |
| SCHEMBL8627275 | 0.67 | CYP3A4 (0.36) | CA12CA9CA1CA2CA14 | |
| SCHEMBL8625943 | 0.66 | GAA (0.35) | CA12CA9TDP1GAA | |
| SCHEMBL8626262 | 0.66 | CA12 (0.43) | CA12CA9CA1CA2CA14 | |
| SCHEMBL16724490 | 0.65 | GAA (0.48) | CYP3A4ADORA3ADORA2AKDM4EALDH1A1 | |
| SCHEMBL8624828 | 0.64 | GRIA2 (0.45) | CA12CA9CA1CA2CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |