Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 5/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675630 | 0.83 | CAPN1 (0.48) | CALCRLCAPN1KEAP1RAMP1CTSB | |
| SCHEMBL8624746 | 0.83 | RAMP3 (0.51) | CAPN1KEAP1OPRM1OPRD1 | |
| SCHEMBL8624738 | 0.83 | RAMP3 (0.51) | CAPN1KEAP1OPRM1OPRD1 | |
| SCHEMBL8643257 | 0.83 | KEAP1 (0.47) | CALCRLKEAP1 | |
| SCHEMBL8643264 | 0.83 | KEAP1 (0.47) | CALCRLKEAP1 | |
| SCHEMBL30335608 | 0.83 | KEAP1 (0.49) | CALCRLCAPN1KEAP1SLC6A2 | |
| SCHEMBL26186082 | 0.83 | KEAP1 (0.49) | CALCRLCAPN1KEAP1SLC6A2 | |
| SCHEMBL26186023 | 0.83 | KEAP1 (0.49) | CALCRLCAPN1KEAP1SLC6A2 | |
| SCHEMBL8624378 | 0.82 | RAMP3 (0.50) | KEAP1OPRM1OPRD1OPRK1 | |
| SCHEMBL8624366 | 0.82 | RAMP3 (0.50) | KEAP1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5786205-A | ISOLATED PURIFIED DNA ENCODING A POLYPEPTIDE BACTERICIDE FOR TREATING GRAMPOSITIVE BACTERIA INFECTION | THE ROCKEFELLER UNIVERSITY (US) | 1998-07-28 | — | — | US | disclosed |
| US-5616686-A | INCLUDING A SEQUENCE OF AMINO ACIDS CORRESPONDING TO THAT RESPONSIBLE FOR ANCHORING A VIRULENCE DETERMINANT PROTEIN TO THE SURFACE OF A GRAMPOSITIVE COCCAL BACTERIA | THE ROCKEFELLER UNIVERSITY (US) | 1997-04-01 | — | — | US | disclosed |