Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8629245 | 0.90 | ALDH1A1 (0.37) | ALDH1A1LMNASMN1; SMN2THRBMAPT | |
| SCHEMBL8627414 | 0.85 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2THRBMAPT | |
| SCHEMBL8761102 | 0.78 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2THRBMAPT | |
| SCHEMBL8626608 | 0.77 | KDM6B (0.41) | ALDH1A1LMNASMN1; SMN2CYP3A4CA12 | |
| SCHEMBL8761359 | 0.76 | ALDH1A1 (0.45) | ALDH1A1LMNASMN1; SMN2MAPTNPC1 | |
| SCHEMBL6619663 | 0.76 | LATS1 (0.40) | LMNASMN1; SMN2POLBKDM4C | |
| SCHEMBL719010 | 0.75 | NPC1 (0.47) | ALDH1A1LMNASMN1; SMN2THRBMAPT | |
| SCHEMBL394795 | 0.75 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2THRBMAPT | |
| SCHEMBL6618966 | 0.75 | L3MBTL1 (0.32) | ALDH1A1LMNASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL8286622 | 0.74 | CA12 (0.62) | ALDH1A1LMNASMN1; SMN2THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |