SCHEMBL8628125

SCHEMBL8628125

CCC1=NC(C)(C)C(=O)O1

nearest known ligand 0.30

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.30
CYP3A4 P08684 3/20 0.30
MAPK1 P28482 3/20 0.30
HIF1A Q16665 2/20 0.30
LMNA P02545 2/20 0.30
CYP1A2 P05177 2/20 0.30
SMN1; SMN2 Q16637 2/20 0.30
NPC1 O15118 2/20 0.30
RAB9A P51151 2/20 0.30
NFKB1 P19838 1/20 0.30
THPO P40225 1/20 0.30
PPM1B O75688 1/20 0.30
PTPN1 P18031 1/20 0.30
PPP1CC P36873 1/20 0.30
TFPI2 P48307 1/20 0.30
PPP5C P53041 1/20 0.30
PPP2CA P67775 1/20 0.30
PPP1CA P62136 1/20 0.30
KDM4E B2RXH2 1/20 0.30
GMNN O75496 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6698827 0.84 TP53 (0.31) TP53CYP3A4MAPK1HIF1ALMNA
SCHEMBL7752813 0.84 TP53 (0.31) TP53CYP3A4MAPK1HIF1ALMNA
SCHEMBL2850217 0.80
SCHEMBL13783711 0.80
SCHEMBL13957070 0.80
SCHEMBL19790038 0.78
SCHEMBL6699147 0.78
SCHEMBL7752907 0.78
SCHEMBL6463410 0.77 CDC25B (0.36) TP53MAPK1PTPN1KDM4EMEN1
SCHEMBL19790033 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10232078-B2 Curable polymeric materials and methods of using same 3M INNOVATIVE PROPERTIES COMPANY (US) 2019-03-19 US disclosed
US-20190038799-A1 CURABLE POLYMERIC MATERIALS AND METHODS OF USING SAME SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2019-02-07 US disclosed
US-20180022864-A1 HYDROCARBON POLYMERS HAVING TWO AZLACTONE END GROUPS BOSTIK SA (FR) 2018-01-25 US disclosed
US-20180022864-A1 HYDROCARBON POLYMERS HAVING TWO AZLACTONE END GROUPS BOSTIK SA (FR) 2018-01-25 US disclosed
WO-2017112456-A1 CURABLE POLYMERIC MATERIALS AND METHODS OF USING SAME 3M INNOVATIVE PROPERTIES COMPANY (US) 2017-06-29 WO disclosed
US-8067581-B2 Biomolecules having multiple attachment moieties for binding to a substrate surface SANOFI-AVENTIS S.A. (DE) 2011-11-29 US disclosed
US-20110201080-A1 BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE SANOFI-AVENTIS S.A. (FR) 2011-08-18 US disclosed
US-7833715-B1 Biomolecules having multiple attachment moieties for binding to a substrate surface NANOGEN RECOGNOMICS GMBH (DE) 2010-11-16 US disclosed
US-20100286377-A1 BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE NANOGEN RECOGNOMICS GMBH 2010-11-11 US disclosed
US-20090124875-A1 Implantable Creatinine Sensor and Related Methods CARDIAC PACEMAKERS, INC. (US) 2009-05-14 US disclosed
US-7186813-B1 Biomolecules having multiple attachment moieties for binding to a substrate surface NANOGEN RECOGNOMICS GMBH (DE) 2007-03-06 US disclosed
EP-0480568-B1 Post-processing stabilization of photothermographic emulsions MINNESOTA MINING & MFG (US) 1998-06-10 EP disclosed
US-5175081-A Post-processsing stabilization of photothermographic emulsions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-12-29 US disclosed
EP-0480568-A2 Post-processing stabilization of photothermographic emulsions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180022864-A1 HYDROCARBON POLYMERS HAVING TWO AZLACTONE END GROUPS H1-2, H1-0, H1-4 TP53 4227/4885CYP3A4 2037/4885MAPK1 2848/4885
US-20110201080-A1 BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE RNGTT, PNKP, MTAP TP53 1091/4885CYP3A4 4510/4885MAPK1 3528/4885
US-20100286377-A1 BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE SSB, EPCAM, BPGM TP53 1990/4885CYP3A4 4231/4885MAPK1 3060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.