SCHEMBL8628177

SCHEMBL8628177

CCOC(=O)c1ccsc1C=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.50
CA12 O43570 4/20 0.46
CA1 P00915 4/20 0.46
CA2 P00918 4/20 0.46
CA7 P43166 4/20 0.46
CA9 Q16790 4/20 0.46
CA14 Q9ULX7 4/20 0.46
ALDH1A1 P00352 5/20 0.46
HSD17B10 Q99714 2/20 0.44
GAA P10253 3/20 0.41
CYP3A4 P08684 2/20 0.41
KDM4E B2RXH2 2/20 0.41
MAPT P10636 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
USP2 O75604 1/20 0.41
KMT2A Q03164 2/20 0.40
RAB9A P51151 2/20 0.40
HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2145329 0.82 TSHR (0.57) TSHRALDH1A1HSD17B10CYP3A4KDM4E
SCHEMBL8464477 0.81 KMT2A (0.49) TSHRCA12CA1CA2CA7
SCHEMBL1844052 0.79 TSHR (0.57) TSHRCA12CA1CA2CA7
SCHEMBL27581813 0.78 TSHR (0.47) TSHRCA12CA1CA2CA7
SCHEMBL162212 0.77 TSHR (0.55) TSHRCA12CA1CA2CA7
SCHEMBL5078857 0.77 TSHR (0.55) TSHRCA12CA1CA2CA7
SCHEMBL8565732 0.77 CA12 (0.36) CA12CA1CA2CA9CA14
SCHEMBL6643211 0.76 ALDH1A1 (0.53) TSHRALDH1A1HSD17B10GAACYP3A4
SCHEMBL28358271 0.76 TSHR (0.53) TSHRCA12CA1CA2CA7
SCHEMBL28618971 0.76 TSHR (0.53) TSHRCA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024153155-A1 DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 成都微芯药业有限公司 2024-07-25 WO disclosed
WO-2023165262-A1 THIENO-NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF 上海科技大学 2023-09-07 WO disclosed
WO-2023165262-A1 THIENO-NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF 上海科技大学 2023-09-07 WO disclosed
CN-116693545-A Thieno nitrogen-containing heterocyclic compound, pharmaceutical composition containing same, preparation method and application thereof 上海科技大学 2023-09-05 CN disclosed
CN-111606928-A Azacyclodiketone compound and preparation method thereof 维清生物科技(上海)有限公司 2020-09-01 CN disclosed
CN-111217810-A Azacyclodiketone compound and preparation method thereof 维清生物科技(上海)有限公司 2020-06-02 CN disclosed
US-5840917-A ADMINISTERING TO MAMMAL TO ERADICATE HELICOBACTER PYLORI TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-11-24 US disclosed
WO-1998042347-A1 PHARMACEUTICAL COMPOSITION CONTAINING A PHOSPHORYLAMIDE AND AN AYNTIBIOTIC TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-01 WO disclosed
EP-0852498-A1 PHOSPHORYLAMIDES, THEIR PREPARATION AND USE Takeda Chemical Industries, Ltd. (JP) 1998-07-15 EP disclosed
WO-1997011705-A1 PHOSPHORYLAMIDES, THEIR PREPARATION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-04-03 WO disclosed