Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992502 | 0.82 | CYP3A4 (0.51) | ALDH1A1KMT2AMEN1USP2TSHR | |
| SCHEMBL11638233 | 0.80 | PTK2 (0.59) | ALDH1A1KMT2AMEN1TSHRLMNA | |
| SCHEMBL7842718 | 0.79 | TSHR (0.46) | ALDH1A1KMT2AMEN1USP2TSHR | |
| SCHEMBL15440489 | 0.79 | HPGD (0.53) | ALDH1A1KMT2AMEN1TSHRNR2F2 | |
| SCHEMBL6636910 | 0.79 | TSHR (0.46) | ALDH1A1KMT2AMEN1USP2TSHR | |
| SCHEMBL31469754 | 0.78 | MEN1 (0.50) | ALDH1A1KMT2AMEN1USP2NR2F2 | |
| SCHEMBL9396580 | 0.78 | MEN1 (0.48) | ALDH1A1KMT2AMEN1USP2TSHR | |
| SCHEMBL9398335 | 0.77 | PKM (0.47) | ALDH1A1KMT2AMEN1USP2TSHR | |
| SCHEMBL8628177 | 0.76 | TSHR (0.50) | ALDH1A1KMT2AMEN1USP2TSHR | |
| SCHEMBL1977053 | 0.76 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015114663-A1 | NOVEL THIENO [2,3-D]PYRIMIDIN-4(3H)-ONE COMPOUNDS WITH ANTIMYCOBACTERIAL PROPERTIES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-08-06 | — | — | WO | disclosed |
| EP-1018514-B1 | NF-$g(k)B INHIBITORS CONTAINING INDAN DERIVATIVES AS THE ACTIVE INGREDIENT | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2004-05-12 | — | — | EP | disclosed |
| US-6734180-B1 | NF-κB inhibitor comprising an indan derivative as an active ingredient | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2004-05-11 | — | — | US | disclosed |
| US-6703421-B1 | ADMINISTERING NF-KAPPA B INHIBITOR | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2004-03-09 | — | — | US | disclosed |
| US-6541630-B1 | 7-bromo-3-methyl-3,4- dihydrothieno(3,2-d)pyrimidin-4-one | AGREVO UK LIMITED (GB) | 2003-04-01 | — | — | US | disclosed |
| EP-0982992-B1 | Use of thienopyrimidines as fungicides | AVENTIS CROPSCIENCE UK LTD (GB) | 2002-09-25 | — | — | EP | disclosed |
| US-6432964-B1 | A THIENYLPYRIMIDINE COMPOUND | AGREVO UK LIMITED (GB) | 2002-08-13 | — | — | US | disclosed |
| EP-1132093-A1 | PREVENTIVES OR REMEDIES FOR MYOCARDITIS, DILATED CARDIOMYOPATHY AND CARDIAC INSUFFICIENCY CONTAINING NF-KAPPA B INHIBITORS AS THE ACTIVE INGREDIENT | SUNTORY LIMITED (JP) | 2001-09-12 | — | — | EP | disclosed |
| EP-1018514-A1 | NF-$g(k)B INHIBITORS CONTAINING INDAN DERIVATIVES AS THE ACTIVE INGREDIENT | SUNTORY LIMITED (JP) | 2000-07-12 | — | — | EP | disclosed |
| EP-0982992-A1 | FUNGICIDES | AgrEvo UK Limited (GB) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998049899-A1 | FUNGICIDES | AGREVO UK LIMITED (GB) | 1998-11-12 | — | — | WO | disclosed |
| EP-0452002-A2 | Thienopyrimidine derivatives | DOWELANCO (US) | 1991-10-16 | — | — | EP | disclosed |
| US-4108867-A | 2-Aminothiophenes | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-08-22 | — | — | US | disclosed |