Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826039 | 0.86 | MAPT (0.56) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL8633261 | 0.85 | MAPT (0.47) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL8628964 | 0.81 | KMT2A (0.50) | SMN1; SMN2ALDH1A1KDM4EMEN1HTT | |
| SCHEMBL8627855 | 0.78 | HPD (0.45) | MAPTSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL8746685 | 0.78 | MAPT (0.62) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL10870559 | 0.78 | MAPT (0.71) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL3885683 | 0.77 | CFTR (0.54) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL5329375 | 0.76 | ALDH1A1 (0.50) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL5323321 | 0.76 | ALDH1A1 (0.50) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL5004832 | 0.76 | ALDH1A1 (0.69) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |