Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565261 | 0.95 | PDE3B (0.47) | PDE3BPDE3AP2RY12MAOB | |
| SCHEMBL6567189 | 0.91 | THRA (0.48) | PDE3BPDE3AP2RY12MAOB | |
| SCHEMBL6565238 | 0.87 | PDE3B (0.47) | PDE3BPDE3AP2RY12MAOBKMT2A | |
| SCHEMBL1509148 | 0.82 | EGLN1 (0.50) | PDE3BPDE3AP2RY12 | |
| SCHEMBL6567169 | 0.81 | ALDH1A1 (0.52) | PDE3BPDE3AMAPK1KMT2AHDAC8 | |
| SCHEMBL6565239 | 0.79 | PDE3B (0.49) | PDE3BPDE3AMAPK1KMT2AHDAC8 | |
| SCHEMBL8628372 | 0.78 | MEN1 (0.52) | MAOBKMT2AHDAC8KDM4EMEN1 | |
| SCHEMBL8628688 | 0.78 | HTT (0.41) | PDE3BPDE3AP2RY12LMNAKMT2A | |
| SCHEMBL964980 | 0.77 | EGLN1 (0.50) | PDE3BPDE3ALMNAALDH1A1 | |
| SCHEMBL6565253 | 0.77 | TDP1 (0.43) | KMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |