Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326736 | 0.91 | ATM (0.62) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL28172083 | 0.90 | AKR1C3 (0.59) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL13252224 | 0.90 | POLB (0.56) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL31541257 | 0.89 | KMT2A (0.66) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL2885036 | 0.89 | KMT2A (0.66) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL10828905 | 0.88 | GAA (0.56) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL8426419 | 0.84 | KMT2A (0.57) | POLBKDM4EATMKMT2AALDH1A1 | |
| N-Methylanthranilic Acid SCHEMBL130356 | 0.84 | KDM4E (0.64) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL6964053 | 0.84 | KDM4E (0.64) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL848499 | 0.84 | POLB (0.64) | POLBKDM4EATMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104119285-B | Compound and application thereof as estrogen-related receptor modulator | 中国科学院广州生物医药与健康研究院 | 2016-06-29 | — | — | CN | claimed |
| CN-104119285-A | Compound used as estrogen-related receptor regulator and application of compound | GUANGZHOU INST BIOMED & HEALTH | 2014-10-29 | — | — | CN | claimed |
| CN-104940202-B | Inhibitors of influenza viruses replication | 沃泰克斯药物股份有限公司 | 2018-10-16 | — | — | CN | disclosed |
| CN-104119285-B | Compound and application thereof as estrogen-related receptor modulator | 中国科学院广州生物医药与健康研究院 | 2016-06-29 | — | — | CN | disclosed |
| CN-104151312-B | Inhibitors of influenza viruses replication | 沃泰克斯药物股份有限公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-104940202-A | Inhibitors of influenza viruses replication | VERTEX PHARMA | 2015-09-30 | — | — | CN | disclosed |
| CN-104922128-A | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA | 2015-09-23 | — | — | CN | disclosed |
| CN-102458408-B | Inhibitors of influenza virus replication | VERTEX PHARMA | 2015-06-03 | — | — | CN | disclosed |
| CN-104151312-A | Inhibitors of influenza viruses replication | VERTEX PHARMA | 2014-11-19 | — | — | CN | disclosed |
| CN-104119285-A | Compound used as estrogen-related receptor regulator and application of compound | GUANGZHOU INST BIOMED & HEALTH | 2014-10-29 | — | — | CN | disclosed |
| CN-102458408-A | Inhibitors of influenza virus replication | VERTEX PHARMA | 2012-05-16 | — | — | CN | disclosed |
| CN-1053438-C | Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI SA (FR) | 2000-06-14 | — | — | CN | disclosed |
| US-5798353-A | Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI (FR) | 1998-08-25 | — | — | US | disclosed |
| CN-1126207-A | Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them | SANOFI SA (FR) | 1996-07-10 | — | — | CN | disclosed |